Oxidization of LDL Cholesterol
Oxidized LDL cholesterol can be found in atherosclerotic lesions. Oxidized LDL cholesterol creates a chronic inflammatory response which promotes the destruction of blood vessels. It accelerates lesion progression by enhancing monocyte adhesion and macrophage foam cell generation, which induces the lesion to migrate onto smooth muscle cells. Oxidized LDL cholesterol also contributes to plaque formation by triggering thrombosis and by impairing vasodilation of the arteries. All of these factors contribute to the progression of atherosclerosis, thereby increasing the risk of a heart attack or stroke. Policosanol has been shown to protect against the oxidation of LDL cholesterol. [2]
References
1. Gouni-Berthold, I. and H.K. Berthold, Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J, 2002. 143(2): p. 356-65.
2. Menendez, R., et al., Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D003, a mixture of very long-chain saturated fatty acids. Can J Physiol Pharmacol, 2002. 80(1): p. 13-21.
About the author:
Dr. Steriti is a graduate of Southwest College of Naturopathic Medicine, an accredited medical school that teaches both conventional diagnosis and alternative therapies, including clinical nutrition, botanical medicine and classical homeopathy. Dr. Steriti's web site is http://www.naturdoctor.com
For more info on policosanol, please visit http://www.lifexpand.com
Written By: Ronald Steriti, ND, PhD

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